ChemStress

ChemStress is ValitaCell’s innovative technology used to improve your process analytics

ChemStress technology allows cells and media functional characterization by mimicking bioprocessing stressful conditions in a SMALL-SCALE model & EARLY in the process. Combining ChemStress biological relevant outputs with advanced analytics, we support our customers to achieve the highest level of bioprocess performance.

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Biologics & Cell Therapy Applications

ChemStress technology enables both clone & media robustness testing in a small-scale system, early in the process, and in an efficient & data-rich way.

Incubate your cells and/or media with the ChemStress 96-well plate chemicals and simply use a standard plate reader to measure cell viability and titer in a small-scale simulated production bioreactor environment.

ValitaCell’s R&D team is currently working on the development of the first innovative characterization assay for primary cells and media in the cell therapy space.

CHO Clone Robustness

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CHO Media Robustness

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Principle of ChemStress Technology

Clone & Media quality and robustness assessment enabled by ChemStress allows you to look far beyond the standard quality assurance analytics that relies only on cell viability and titer measurements.

Validate the robustness of your media, select your best media formulation and profile your clones by assessing deep cell functional activity under stressful conditions mimicking known bioprocess stresses and challenging key metabolic pathways in a small-scale model and early in the process.

Cells are challenged with a panel of selected categories of 21 small molecule chemicals challenging key production pathways and mimicking recurrent bioprocess stresses cells are likely to experience in production.

ChemStress Applications

Media and clone routine testing and characterization is critical during Cell Line Development, through Process Scale-Up and Optimization, and especially before starting and during Manufacturing. ChemStress can be flexibly integrated into your standard QC testing at any stage providing more confidence to bring forward a specific media lot, the most robust media formulation, or your best clones.

ChemStress Workflow

 

Expose cells to stressors
Incubate the cells for 72 hours

 

Measure biological readout (e.g.cell growth &/or titer) with a standard plate reader

 

 

Advanced data analysis
Rich functional information

 

Incubate your cells and/or media with the ChemStress 96-well plate chemicals and simply use a standard plate reader to measure cell viability and titer in a small-scale simulated production bioreactor environment.

How do I empower my process with ChemStress?

 

Outsourcing service 

 

Ship your media or clone to our lab and get results.

Run ChemStress in ValitaCell’s fully optimized automated platform.

 

In-House service

 

Get lab and data analysis consultancy service in your lab.

Run ChemStress in your lab with ValitaCell scientists’ consultancy.

Resources

Cell culture patent

ChemStress Chemicals Specification

Product brochure: ChemStress Robustness assay